Oxygen-binding curve

We can determine quantitatively the physiological significance of the sigmoid nature of the hemoglobin oxygen-binding curve, or, in other words, the biological importance of cooperativity. The equation... 

The experimentally observed oxygen-binding curve for Hb does not fit the graph given in Figure A15.3 exactly. If we generalize Equation (A15.10) by replacing the exponent 4 by n, we can write the equation as... 

The qualitative relationship between the oxygen binding curves for hemoglobin and myoglobin. 

Figure 13.5 (a) The structure of sperm whale myoglobin. (From Voet and Voet, 2004. Reproduced with permission from John Wiley Sons., Inc.) (b) The oxygen-binding curves of myoglobin and haemoglobin. (Reprinted with permission from Collman et al., 2004. Copyright (2004) American Chemical Society.)... 

Thus, for hemoglobin (Hb) the oxygen binding curves are sigmoidal as is shown in the above figure. The fact that n exceeds the unit can be ascribed physically to the fact that attachment of O2 to one heme group... 

Figure 10.1 The oxygen-binding curves of (a) myoglobin and (b) hemoglobin.

Two quite different models were proposed about 25 years ago to explain the unusual nature of the hemoglobin oxygen-binding curve (fig. 5.14). These models can also be used as a starting point for discussing other allosteric proteins. The first model, introduced by Jacque Monod, Jeffery Wyman, and Pierre Changeux in 1965, is called the symme-... 

Hemoglobin has been a favorite protein molecule for designing and testing various models of the molecular basis of subunit interactions in multisubunit proteins. In the 1960s, two mechanisms were advanced to account for the sigmoidal nature of the oxygen binding curve for Hb A, one proposed by Monod et al. (1965) based on a... 

The oxygen binding curves for Mb and Hb, showing the pH dependence for the latter. 

The oxygen-binding curves for myoglobin(Mb) and haemoglobin(Hb), showing also the pH-dependence(Bohr effect). 

Oxygen-binding curves can be analyzed directly to yield fonr macroscopic binding constants K, K2, M3, and K4. Usnally, the macroscopic constants are defined as prodnct constants, i.e., products of the stepwise macroscopic constant (where i... 

Oxygen binding curve is a characteristic sigmoidal ("S") shape. 

The oxygen binding curve for hemoglobin is shown in Figure 1-12. In the presence of CO2, the partial pressure of 02 required for any given fraction of... 

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