Oxycodone/acetaminophen

Oxycodone Acetaminophen (Percocet, Tylox) Oxycodone Aspirin (Percodan, Percodan-Demi) Oxycodone/Ibuprofen (Combunox) Oxymorphone (Opana, Opana ER)... 

Oxycodone/acetaminophen (generic, Percocet, Tylox, others)... 

Oxycodone/acetaminophen (generic, Percocet, Tylox, others). Note High-dose acetaminophen has potential for hepatic toxicity with repeated use. 

The opioid analgesics of choice for use in the elderly are listed in Box 7-3. For treatment of moderate to severe pain, an effective opioid regimen consists of a combination of acetaminophen with 15 to 60 mg codeine or acetaminophen with 5 to 30 mg oxycodone. Acetaminophen combinations with hydrocodone are also frequently used. If pain persists, an alternative opioid analgesic should be selected. Adjuvants such as caffeine may enhance the analgesic activity of the opioid. 

E Oxycodone/acetaminophen would be the most appropriate drug to start for this patient s acute postsurgical pain. The onset of action is rapid, and it can be titrated to effect. Morphine and meperidine have active metabolites that can accumulate in this patient with renal dysfunction, increasing the risk for seizures, sedation, and respiratory depression. The fentanyl patch is primarily indicated in chronic pain. The onset is slow, and the patches cannot be titrated up rapidly to cover acute pain, nor titrated down as the patient recovers and requires less opioid. 

Canada has the dubious distinction of having the world s largest per capita consumption of precursor opiate-containing compounds (e g., codeine, oxycodone, and hydrocodone) (Korcok 1979). A drug utilization review of opiate use in Canada from 1978 to 1989 shows continued increase in the use of prescribed codeine combination products. The defined daily dose (DDD)/1000 inhabitants/day for prescribed codeine-acetaminophen products has increased from 3.3 DDD/1000 inhabitants/day in 1982 to 8.1 DDD/1000 inhabitants/day in 1989. Oxycodone-acetaminophen containing products have also been increasing from 0.04 DDD/1000 inhabitants/day in 1978 to 0.21... 

OXYCODONE/A CET AMTNOPHEN (Percocet tablets 5 mg oxycodone hydrochloride/325 mg acetaminophen, tablets 7.5 mg oxycodone hydrochloride/500 mg acetaminophen, tablets 10 mg oxycodone hydrochloride/650 mg acetaminophen, Roxicet tablets 5 mg oxycodone hydrochloride/325 mg acetaminophen, solution, oral 5 mg oxycodone hydrochloride/325 mg acetaminophen, Roxicet 5/500 caplets 5 mg oxycodone/500 mg acetaminophen, Roxilox capsules 5 mg oxycodone hydrochloride/500 mg acetaminophen, Tylox capsules 5 mg oxycodone hydrochloride/500 mg acetaminophen) Oxycodone/acetaminophen is an opioid analgesic combination. Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas oxycodone binds to opiate receptors in the CNS. Their combination has a synergistic effect in alleviating pain. It is indicated in the relief of moderate to moderately severe pain. 

Peigolizzi IV Jr, Taylor R Jr, Raffa RB (2015) The potential role of an extended-release, abuse-deterrent oxycodone/acetaminophen fixed-dose combination product for the treatment of acute pain. Adv Ther 32 485-495... 

Epidural PCA is maintained for 2-4 days, depending upon the procedure and potential benefit to the patient. Most patients make a smooth transition to oral opioids such as oxycodone or oxycodone-acetaminophen compounds, or to low-dose IV-PCA therapy for some who remain nil per os (NPO) for extended periods. For opioid-dependent or chronic... 

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