8-oxoguanine DNA glycosylase

Nash HM, Bruner SD, Scharer OD et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6 968-80... 

Kreklau EL, Limp-Foster M, Liu N, Xu Y, Kelley MR, Erickson LC (2001) A novel fluorometric oligonucleotide assay to measure O(6)-methylguanme DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase. Nucleic Acids Res 29 2558-66... 

Rosenquist TA, Zharkov DO, Grollman AP (1997) Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci USA 94 7429-34 Croteau DL, ap Rhys CMJ, Hudson EK, Dianov GL, Hansford RG, Bohr VA (1997) An oxidative damage-specific endonuclease from rat liver mitochondria. J Biol Chem 272 27338-44... 

Sidorenko, V.S., Nevinsky, G.A., and Zharkov, D.O. (2007) Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease. DNA Repair, 6, 317-328. 

Girard, P. M., Guibourt, N., and Boiteux, S. (1997). The Oggl protein of Saccharomyces cerevisiae A 7,8-dihydro-8-oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity. Nucleic Adds Res. 25, 3204-3211. 

Nash, H. M., Bruner, S. D., Scharer, O. D., Kawate, T., Addona, T. A., Spooner, E., Lane, W. S., and Verdine, G. L. (1996). Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr. Biol. 6, 968-980. 

Tchou J, Kasai H, Shibutani S et al. (1991) 8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc Natl Acad Sci USA 88 4690-4 Bessho T, Tano K, Kasai H, Ohtsuka E,Nishimura S (1993) Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanme) in human cells. J Biol Chem 268 19416-21... 

T.K. Hazra et al., Repair of hydantoins, one electron oxidation product of 8-oxoguanine by DNA glycosylases of Escherichia coli. Nucleic Acids Res. 29, 1967-1974 (2001)... 

Fromme, J., Banerjee, A., Huang, S.J., and Verdine, G.L (2004) Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Nature, 427, 652-656. 

Fig. 5. Comparison of 8-oxoguanine binding to the active sites of two different 8-oxoguanine glycosylases. The oxoG base is shown in red, DNA in gold, and enzyme residues in cyan. (A) hOGGl active site (Bruner et al., 2000). (B) MutM active site (Fromme and Verdine, 2003a). Both panels used with permission. (See Color Insert.)...

Hang, B., Singer, B., Margison, G. P., and Elder, R. H. (1997). Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of l,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine. Proc. Natl. Acad. Sci. USA 94, 12869-12874. 

Morland, 1., Rolseth, V., Luna, L., Rognes, T., Bjoras, M., and Seeberg, E. (2002). Human DNA glycosylases of the bacterial Fpg/MutM superfamily An alternative pathway for the repair of 8-oxoguanine and other oxidadon products in DNA. 

Noll, D. M., Gogos, A., Granek, J. A., and Clarke, N. D. (1999). The C-terminal domain of the adenine-DNA glycosylase MutYconfers specificity for 8-oxoguanine.adenine... 

---