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Oxocines

SEVEN-, EIGHT-MEMBERED AND LARGER HETEROCYCLIC RINGS [Pg.676]

It is used in clinical medicine against infections caused by Gram-positive bacteria. It is also used for many pulmonary infections such as Legionnaire s disease and as an alternative therapy in patients allergic to penicillins. [Pg.676]

The biosynthesis of erythromycin can be divided into two phases. In the first phase, the polyketide synthase (PKS) catalyzes sequential condensation of one unit of pro-pionyl CoA and six units of methylmalonyl CoA to give 6-deoxyerythronolide B, the first enzyme-free intermediate [75]. In the second phase, 6-deoxyerythronolide B is elaborated by a series of tailoring enzymes, which include regiospecific hydroxylases, glycosyl transferases, and methyl transferases. [Pg.676]

Dibenz[6,/]oxepin, 10,11-dihydro-applications, 7, 590 Dibenz[c,e]oxepin, dihydro-conformational interchange, 7, 549 Dibenz[6,/]oxepinylpiperazine, 10,11-dihydro-properties, 7, 590 Dibenz[6,g]oxocin synthesis, 7, 669... [Pg.603]

H-Oxocin-3-one, 2,3,7,8-tetrahydro-synthesis, 7, 667 Oxocins, 7, 668-669 47/-Oxocins synthesis, 7, 669 Oxocinyl anions aromaticity, 7, 669 Oxoiron compounds high valent... [Pg.736]

Sulfonyl- 1,6-dihydroazocinedicarboxylates (77) are formed by valence isomerization of the cis- azabishomobenzenes (76) at 125 °C, but the compounds are unstable at this temperature and were characterized only by spectra (76CB3505). These azocines are completely monocyclic, and exhibit no valence isomerization, in contrast to the corresponding 6H-oxocins. [Pg.661]

Treatment of 7-chloro-2-oxabicyclo[4.2.0]oct-4-en-3-ones 4 with triethylamine in ethanol under reflux gave oxocin-2-ones 5 in very good yields.185... [Pg.597]

Miginiac et al. [97] synthesized oxepin 233 and oxocin 234 starting from allyl-silane silyl ether 237, which was condensed with various aldehydes in the presence of Et20 BF3 (1.0 equivalent) (Scheme 13.85). The resulting seven- and eight-membered rings were obtained in moderate to excellent yields. [Pg.443]

Similar rearrangement occurred in some related substrates bearing one hydroxymethyl and one cyano or phenylsulphonyl group. Also, a cyclobutane homologue was transformed to a formyl dihydro-oxocin ... [Pg.209]

See other pages where Oxocines is mentioned: [Pg.40]    [Pg.40]    [Pg.735]    [Pg.735]    [Pg.736]    [Pg.736]    [Pg.41]    [Pg.41]    [Pg.94]    [Pg.113]    [Pg.113]    [Pg.113]    [Pg.113]    [Pg.23]    [Pg.653]    [Pg.654]    [Pg.666]    [Pg.667]    [Pg.668]    [Pg.669]    [Pg.669]    [Pg.597]    [Pg.142]    [Pg.653]    [Pg.654]    [Pg.661]    [Pg.666]    [Pg.667]    [Pg.668]    [Pg.669]    [Pg.669]    [Pg.40]    [Pg.40]    [Pg.735]    [Pg.735]    [Pg.736]    [Pg.736]    [Pg.947]    [Pg.1073]    [Pg.2538]    [Pg.2560]    [Pg.2575]   
See also in sourсe #XX -- [ Pg.672 ]



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Radicals Containing an Oxocin Ring

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