5- Oxo-4,5-dihydro-2-pyrazinecarboxylic

Methyl 3-oxo-3,4-dihydro-2-pyrazinecarboxylate (22) gave methyl 3-chloro-2-pyrazinecarboxylate (23) (S02C1, trace Me2NCHO, PhMe, 80°C, N2, 3 h 80%) 54 the isomeric substrate, methyl 5-oxo-4,5-dihydro-2-pyrazinecarboxy-late, gave methyl 5-chloro-2-pyrazinecarboxylate (24, R = H) (neat POCl3, trace Me2NCHO, reflux, 2 h 68%) 85 and the homologous methyl 5-chloro-6-methyl-2-pyrazinecarboxylate (24, R = Me) (77%) was made similarly.85... [Pg.141]

Pyrazinecarboxylic acid underwent microbiological hydroxylation to give 3-oxo-3,4-dihydro- (36, R = H) (Alcaligenes eutrophus 70%), 5-oxo-4, 5-dihydro- (37) (.Pseudomonas acidovorans 96%), or 6-oxo-l,6-dihydro-2-pyrazinecarboxylic acid (38) (Alcaligenes faecalis 85%) 1091 Similar procedures afforded 5-chloro-3-oxo-3,4-dihydro-2-pyrazinecarboxylic acid (Alcaligenes eutrophus 50%) and 5-oxo-4,5-dihydro-2-pyrazinecarbonitrile (Agrobacterium sp 78%).1091... [Pg.195]

Methyl-3-oxo-3,4-dihydro-2-pyrazinecarboxylic acid (33, R = H) gave ethyl 5-methyl-3-oxo-3,4-dihydro-2-pyrazinecarboxylate (33, R = Et) (EtOH, HC1 gas, 0°C then 20°C, 12 h then reflux 2 h 58%).646... [Pg.304]

Ethyl 6-methyl-5-(2-methylthioethyl)-3-oxo-3,4-dihydro-2-pyrazinecarboxylate Ethyl 5-methyl-3-oxo-3,4-dihydro-... [Pg.422]

Methyl 3-bromo-6-chloro-5-dimethylamino-2-pyrazinecarboxylate Methyl 3-bromo-6-chloro-5-ethylamino-2-pyrazinecarboxylate Methyl 3-bromo-6-chloro-2-pyrazinecarboxylate Methyl 6-bromo-3-cyclopropylamino-2-pyrazinecarboxylate Methyl 6-bromo-3-dimethylamino-2-pyrazinecarboxylate Methyl 6-bromo-3-methylamino-2-pyrazinecarboxylate Methyl 6-bromo-3-methylthio-2-pyrazinecarboxylate Methyl 6-bromo-3-oxo-3,4-dihydro-2-pyrazinecarboxylate Methyl 3-bromo-2-pyrazinecarboxylate Methyl 6-bromo-2-pyrazinecarboxylate I-(3-Methyl but-2-cnyl)-2(l //)-pyrazinone 4-oxide... [Pg.443]

Methyl 3-chloro-5,6-diphenyl-2-pyrazinecarboxylate Methyl 6-chloro-5-ethylamino-3-oxo-3,4-dihydro-2-pyrazinecarboxylate... [Pg.444]

Methyl 3-chloroformyl-2-pyrazinecarboxylate Methyl 6-chloro-5-methoxy-3-oxo-3,4-dihydro-2-pyrazinecarboxylate Methyl 6-chloro-3-methoxy-2-pyrazinecarboxylate Methyl 3-chloro-5-methyl-2-pyrazinecarboxylate Methyl 5-chloro-6-methyl-2-pyrazinecarboxylate Methyl 5-chloro-6-methyl-2-pyrazinecarboxylate 1-oxide Methyl 6-chloro-3-nitro-2-pyrazinecarboxylate Methyl 6-chloro-3-oxo-3,4-dihdyro-2-pyrazinecarboxylate... [Pg.444]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...