Oximes protective action

Certain oximes, such as bispyridinium oxime HI 6 and 2-PAM, have been reported to protect against soman toxicity. Pretreatment with HI 6 (50 mg/kg) together with atropine (10 mg/kg) increased the LC50 (LC50 X time) in rats by a factor of 7 (Schoene et al. 1985). HI 6 is an effective reactivator of soman-inhibited acetylcholinesterase. Its protective action was found to be greater in mice than in guinea pigs (Maxwell and Koplovitz 1990). In addition to reactivation of the enzyme acetylcholinesterase inhibited by soman, HI 6 produced an effect on carboxylesterase that... 

Ability of oximes to interact directly with some OPC [58] and also with phosphorylated enzyme [59] is considered as an additional protective mechanism of their action. A value of the reaction indicated for the organism depends upon subsequent fate of the phosphorylated oxime. The formation of less toxic products in case of fast degradation of the phosphorylated oxime is evaluated as the process of OPC detoxication [60], while amplification of the poisoning enzyme toxicity is accompanied with the formation of strong phosphorylated oxime [61], That is the reason why prophylactic use of oximes in the last case can result in the reverse effect. 

Gender differences are observed in the antidotic-and-therapeutic action of oximes. The single administration of an oxime concurrently with atropine protects males from 4.2 DL50 of soman and 2.5 DL50 of tabun, with respective values for females being 10.5 and 4.3 DL50 [79],... 

One-pack polyurethane adhesives can also be manufactured by protecting the isocyanate groups of prepolymers with, for example, phenols or oximes, which are split off by the action of heat during bonding. Protected polyisocyanates can also be added to... 

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