Oxidative Stress and Lung Injury

Three types of SODs occur (1) extracellular (EC)-SOD, (2) manganese SOD found in the mitochondria, and (3) copper-zinc SOD found in the cytosol and nucleus. H202 can be converted to the highly toxic hydroxyl radical ( OH) via the iron-catalyzed Fenton reaction  

Moreover, H202 in the presence of Oy and a divalent metal can also produce OH via the iron-catalyzed Haber-Weiss reaction  

At least three different sources of ROS contribute to oxidative stress in the respiratory system. First, the initial inflammatory response involving macrophage-mediated phagocytosis involves the release of Oy, which is primarly generated by the NADPH oxidase system in these cells. This respiratory burst likely evolved as 

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