Oxidative injury memantine

Gupta, R.C., Milatovic, S., Dettbam, W-D., Aschner, M., Milatovic, D. (2007). Neuronal oxidative injury and dendritic damage induced by carbofuran protection by memantine. Toxicol. Appl. Pharmacol. 219 97-105. 

In conclusion, the data demonstrated that synergistic mechanisms of cellular disruption caused by anti-AChE agents led to cellular dysfxmction and neurodegeneration. It has also been demonstrated that preventing CF-induced neuronal hyperactivity by pretreatment with memantine and atropine blocks pathways associated with oxidative damage in rat brain. The documented ability of memantine therapy to reduce free radical generation and lipid peroxidation, prevent HEPs, and attenuate the morphological injury provides further support for the role of ROS and RNS in anti-AChE-induced seizures. 

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