Oxidation chlorinated hydrocarbon metabolism

Many halogenated hydrocarbons exert toxicity in their native form whereas others are more toxic and exert effects from the intermediates and metabolites formed in the biotransformation for excretion or other purposes. A special group of intermediates or by-products that are formed are different types of very reactive macromolecule and tissue-harming free radicals from carbon, oxygen and chlorine and organic radicals such as CHj", as well as hydrogen peroxide, epoxides and other electrophilic compounds emanating from the oxidative metabolism. 

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