Oxeladin

The resulting mixture was heated under reflux with stirring for 12 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloro-methane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off. 

The residue was recrystallized from ethanol to give 10.6 g of the desired product melting at 186°Cto 188.5°C. 

Chemical Name a ,a -diethylbenzeneacetic acid 2-[2-(diethylamino)ethoxy] ethyl ester Common Name — 

Trade Name Manufacturer Country Year Introduced 

Preparation of Diethylphenylacetonitrile 25 grams of sodium was dissolved in 300 ml liquid ammonia containing 0.3 gram ferric chloride and 59 grams phenylacetonitrile was added slowly with stirring. After about 15 minutes a cooled solution of 80 grams of ethyl chloride in 200 ml dry ether was added and the mixture stirred for 1 hour. The ammonia was then allowed to evaporate, water added and the ether layer separated, dried, concentrated and the residual oil distilled in vacuo to yield diethylphenylacetonitrile as an oil, 

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Oxeladin [468-61-1] (54), an antitussive developed in the UK, is stmcturaHy related to carbetapentane in that the cyclopentane ring has been broken at the 3,4-bond. It is also similar pharmacologically. Extensive clinical studies using cough drops and symp containing oxeladin are described (73). The compound can be synthesized from phenylacetonitrile (74). 

Hydrocortamate HCI Lidocaine Oxeladin Proxazole citrate Rociverine Tilidine HCI T rapidil... 

Ethyl a-bromobutyrate Cyclobutyrol Ethyl bromoisobutyrate Methallenestril Ethyl-2-bromo propionate Naproxen Ethyl carbonate Ibuprofen Ethyl chloride Oxeladin... 

Cj H7N 140-29-4) see Azatadine Dicycloverine Disopyramide Ethoheptazine Isoaminile Levocabastine Mephenytoin Methylphenidate Methylphenobarbital Milnacipran hydrochloride Oxeladin Pentapiperide Pentoxyverine Pethidine Phenglutarimide Pheniramine Phenobarbital Tolazoline Triamterene Valethamate bromide 1 -benzy l-4-cyanopiperidine (C]3H 9N2 62778-37-4) see Ketanserin... 

C4H8CI2O 111-44-4) see Benzethonium chloride Oxeladin Risperidone /V,/V-bis(2-chloroethyl)-N-methylamine (C5H11CI2N 51-75-2) see Ketobemidone Pethidine... 

Oxathiine derivatives lb 301,304 Oxathizine fungicides la 44 Oxazepam la 364 Oxazolidinthione derivatives lb 301 Oxeladine citrate lb 327 Oxidation, aluminium isopropoxide la 59 -, atmospheric oxygen la 60 -, chromic acid la 59, 60 -, hydrogen peroxide la 59 -, iodine la 60... 

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