Oxazolylzinc chloride preparation

Oxazolylzinc chloride, prepared from the corresponding 2-lithiooxazole, underwent... 

Iodooxazole 15, prepared from the corresponding 2-lithiooxazole, underwent a Negishi reaction with 2-oxazolylzinc chloride to give bis-oxazole 16 in the presence of Pd(dba)2 and trifuranylphosphine (TFP) [4]. 

The Merck process chemists found that 2-oxazolylzinc species 40, successfully prepared from oxazole 39 subsequently cross-coupled with aryl or heteroaryl bromides to oxazoles 41. The use of solid zinc chloride helped the transmetallation however, long reaction times were required for good yields. Anderson also reported 2-oxazolylzinc species 40 was successfully cross-coupled with aryl iodides and triflates to compounds 41. This methodology was employed in the synthesis of oxazole-containing partial ergot alkaloids. ... 

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