Oxanamide, synthesis

This aldehyde is an intermediate in the synthesis of the tranquillizer oxanamide. Because both components of the aldol reaction are the same, no special precautions need to be taken to prevent side-reactions occurring. In the synthesis, the dehydration happened spontaneously. 

The synthesis of the minor tranquilliser Oxanamide (31) illustrates how C-X disconnexions and FGI can be added to this genera) plan. The molecule has amide and epoxide FGs. We know of one way to put in each of these groups — by C-N and C-O disconnection — so we must start here and decide the order of events later. This gives us an a,l3-unsaturated acid, so we can disconnect at the double bond. 

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