Tranquillisers minor

The synthesis of the minor tranquilliser Oxanamide (31) illustrates how C-X disconnexions and FGI can be added to this genera) plan. The molecule has amide and epoxide FGs. We know of one way to put in each of these groups — by C-N and C-O disconnection — so we must start here and decide the order of events later. This gives us an a,l3-unsaturated acid, so we can disconnect at the double bond. 

The alkaloids of this type have a similar carbon skeleton to the benzodiazq>ine drugs, known as minor tranquillisers. The first alkaloid of tius type obtained fi om a natural source was puntarenine, isolated fiom Berberis enq>etri/natural source were saulatine and dihydrosaulatine, both isolated fiom Abuta bullata. 

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