Oxalyl chloride, condensation, with

Oxa-7,7-dichloronorcarane, 41, 76 Oxalyl chloride, condensation, with N,N-diethylaniline, 41, 3 with N,N-dimethylaniline, 41, 1 with N,N-di- -propylaniline, 41, 3... 

Antibacterial activity is retained when the relatively complex amide side chains are replaced by a simple heterocycle amidine. The required reagent (7-2) is prepared by reaction of azepine formamide (7-1) with oxalyl chloride. Condensation of the product with 6-APA (2-4) leads to the formation of the amidine and thus amdinocillin (7-3) [11]. 

Cl Vat YeUow 12 is prepared by condensing l-anaino-5-ben2oylaininoanthraquinone [117-06-6] (161) with oxalyl chloride in nitroben2ene. Cl Vat YeUow 33 is prepared by condensation of two moles of 1-aminoanthraquinone with one mole of 4V -a2obis(4-biphenylcarbonyl chloride). Cl Vat Red 21 is prepared from 1,4-diaminoanthraquinone (33) and l-nitroanthraquinone-2-carboxyhc acid (58) by the foUowing process ... 

Condensation, of 2-aminobiphenyl with boron trichloride, 46, 65 of a-chloroacetamide with oxalyl chloride, 46,16... 

Condensation, of oxalyl chloride, with di- -alkylanilines, 41, 3 with dimethylaniline, 41, 1 of 1,1,3,3-tetraethoxypropane with thiourea to give 2-mercaptopy-rimidine, 43, 68... 

Crotonic acid, esterification with sec-butyl alcohol, 41, 60 Crystal Violet, from condensation of oxalyl chloride with dimethyl-aniline, 41, 2-4... 

Acyl hydrazides are useful precursors for the synthesis of 1,2,4-triazoles. Reaction of acyl hydrazides 149 with imidoylbenzotriazoles 148 in the presence of catalytic amounts of acetic acid under microwave irradiation afforded 3,4,5-trisubstituted triazoles 150 <06JOC9051>. Treatment of A-substituted acetamides with oxalyl chloride generated imidoyl chlorides, which reacted readily with aryl hydrazides to give 3-aryl-5-methyl-4-substituted[ 1,2,4]triazoles <06SC2217>. 5-Methyl triazoles could be further functionalized through a-lithiation and subsequent reaction with electrophiles. ( )-A -(Ethoxymethylene)hydrazinecarboxylic acid methyl ester 152 was applied to the one-pot synthesis of 4-substituted-2,4-dihydro-3//-1,2,4-triazolin-3-ones 153 from readily available primary alkyl and aryl amines 151 <06TL6743>. An efficient synthesis of substituted 1,2,4-triazoles involved condensation of benzoylhydrazides with thioamides under microwave irradiation <06JCR293>. 

Parabanic acid can be prepared by the condensation of urea with diethyl oxalate in an ethanolic solution of sodium ethoxide,2 by reaction of urea with an ethereal solution of oxalyl chloride,3 by oxidizing uric acid with an acid solution of perhydrol,4 or by the action of hot, concentrated nitric acid on uric acid.5 The present method gives better yields than the previously reported methods and is better adapted to larger-scale preparations. 

N,N-Diethylaniline, condensation with oxalyl chloride, 41, 3 Diethyl bis(hydsoxymethyl)malo-nate, 40, 27... 

In the first total synthesis of the alkaloid erysotrine, the pyrroloisoquino-line ring 132 was prepared from (5 )-3,4-dimethoxyphenylalanine methyl ester and methyl chloroformylacetate, followed by ring closure and condensation with oxalyl chloride [92H(33)497]. 

A 200-mL, two-necked, round-bottomed flask fitted with a magnetic stirring bar, reflux condenser, and rubber septum is flushed with nitrogen, lo this flask is introduced a dry benzene solution (50 ml) of crude acid 3 through the septum. Then 8.9 mL (12.9 g, 0.101 mol) of oxalyl chloride is slowly added with stirring at room temperature. After the evolution of gas iisisos, the solution is further heated in an oil bath maintained at 70°C for III min. The solvent, together with excess oxalyl chloride, is removed at room... 

D. Condensation of DAMN with Oxalyl Chloride 1. 2,3-Dioxo-5,6-dicyano-l,2,3.4-tetrahydropyrazine... 

Preparation of 2,3-dioxo-5,6-dicyano-l,2,3,4-tetrahydropyrazine (67) by condensation of DAMN with oxalyl cyanide or oxalyl chloride, and by reaction of DISN with oxalyl chloride, followed by the treatment of the intermediate with ethanethiol, was noted in Section V,B,1. 

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