Oxaliplatin adverse effects

Drug(s) Oxaliplatin Primary Antineoplastic Indication(s) Colorectal cancer Common Adverse Effects Blood disorders (anemia, leukopenia, neutropenia, thrombocytopenia) joint pain, chest pain... 

Like carboplatin, oxaliplatin does not usually cause nephrotoxicity. In addition, both drugs are only moderately emetogenic, in contrast to cisplatin. The most important dose-limiting adverse effect of oxaliplatin is a sensory peripheral neuropathy, which has two different forms ... 

Nausea, vomiting, and diarrhea are common adverse effects of oxaliplatin and carboplatin, but they are generally mild to moderate, and both are less emetogenic than cisplatin. However, patients who have previously received cisplatin may be at greater risk of vomiting with carboplatin or oxaliplatin (1,8,9). 

The concomitant use of irinotecan as a 1-hour infusion immediately following a 2-hour infusion of oxaliplatin resulted in more severe hypersalivation and abdominal pain than irinotecan monotherapy (275). Acute intervention with atropine alleviated these adverse effects. When the drugs were separated by 1 day, the cholinergic symptoms were not exacerbated. The authors postulated that oxaliplatin might have some acetylcholinesterase inhibitory activity. 

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