Oxacillin, protein binding

Oxacillin sodium, which is available in capsule form, is teisonably well absorbed from the gastrointestinal tract, par-ivularly in fasting patients. Effective plasma levels of oxa-dllin are obtained in about I hour, but despite extensive plasma protein binding, it is excreted rapidly through the ladney.s. Oxacillin experiences some first-pass metabolism iaihe liver to the S-hydroxymeihyl derivative. This metabolite has antibacterial activity comparable to that of oxacillin... 

Oxacillin (Prostaphlin) Protein-Binding 95% PO 0.5-1 g Every 4—6 hours... 

Oxacillin is bactericidal it adheres to bacterial penidlUn-binding proteins, thns inhibiting bacterial cell wall synthesis. 

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