Overview of Mechanochemical Methodologies

1 Comparison with Solvent-based Co-crystallisation Techniques 

2 Screening for Co-crystals Using Neat and Liquid-assisted Grinding 

An attractive aspect of co-crystallisation in the synthesis of new API forms is the possibility of forming co-crystals containing identical constituents in different stoichiometric ratios.Mechanochemical methods provide a particularly simple procedure for constructing such stoichiometric variations by simply grinding different amounts of starting materials. This was first demonstrated for the model API caffeine upon co-crystallisation with acetic 

The synthesis of stoichiometric variations was systematically investigated for co-crystals of the model API nicotinamide with various dicarboxylic acids. 

Stoichiometric ratio nicotinamide acid Co-crystallisation from solution 1 1 2 1 Co-crystallisation from the melt 1 1 2 1 Neat grinding 1 1 2 1 LAG 1 1 2 1 

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