Overman, Larry

O Brien, Peter, 89 Odom, Aaron L., 170 Ohirn, Susumu, 168 Oi, Shuichi, 98 Overhand, Mark, 83 Overman, Larry, 56, 143, 160... 

Submitted by Peter J. Jessup, C. Bruce Petty, Jan Roos, and Larry E. Overman ... 

Submitted by Larry E. Overman and Gilbert M. RishtonJ Checked by Takashi Ooi and Hisashi Yamamoto. 

Submitted by Rajarathnam E. Reddy and Conrad J. Kowalski.1 Checked by Chang Y. Hong and Larry E. Overman. 

Submitted by Ruen Chu Sun and Masami Okabe.1 Checked by Timothy C. Gahman and Larry E. Overman. 

Submitted by A. K. Beck, S. Blank, K. Job, D. Seebach, and Th. Sommerteld.1 Checked by Frank Narjes and Larry E. Overman. 

Submitted by Hidemasa Takaya,1 Tetsuo Ohta,1, Shin-ichi Inoue,2 Makoto Tokunaga,2 Masato Kitamura,2 and Ryoji Noyori.2 Checked by Andrew Madin and Larry E. Overman. 

Submitted by Takashi Ooi, Keiji Maruoka, and Hisashi Yamamoto.1 Checked by Catherine Gasparski and Larry E. Overman. 

Larry E. Overman Ichiro Shinkai Amos B. Smith, III Hisashi Yamamoto... 

Submitted by M. Hark Midland, Jim I. HcLoughlln, and Ralph T. Werley, Jr. Checked by Matthew J. Sharp and Larry E. Overman. 

Checked by Willi-Kurt Cries and Larry E. Overman. 

Submitted by Larry E. Overman, Mark J. Brown, and Stephen F. McCann. ... 

Larry E. Overman Leo A. Paquette John D. Roberts Gabriel Saucy Dieter Seebach Martin F. Semmelhack Ichiro Shinkai Bruce E. Smart Amos B. Smith. Ill Edwin Vedejs James D. White Kenneth B. Wiberg Ekkehard Winterfeldt Hisashi Yamamoto... 

Larry E. Overman is Distinguished Professor of Chemistry at the Urriversity of California, Irvine. He received a B.A. from Earlham College and a Ph.D. in organic chemistry from University of Wiscortsirt, Madison. He is an organic chemist, specializing in new methods for organic synthesis, rratrrral prodncts synthesis, and medicinal chemistry. Overman is a member of the National Academy of Sciences and served as co-chair of the BCST from 1997 to 2000. 

Marvin H. Caruthers, University of Colorado Liang-Shih Fan, Ohio State University Larry E. Overman, University of California, Irvine Michael J. Sailor, University of California, San Diego Jeffrey J. Siirola, Eastman Chemical Company, Steering Committee and BCST Liaison... 

While secondary alcohols are now relatively easy to prepare in enantiomerically-pure form, secondary amines have been more challenging. Larry Overman of UC Irvine reports (J. Am. Chem. Soc. 125 12412, 2003) the catalytic rearrangement of primary allylic alcohols such as 4 to the corresponding protected vinyl amine 5 with excellent . Hydrolysis of the amine 5 gives the GABA aminotransaminase inhibitor 6. Unnatural amino acids can be prepared by oxidative cleavage of the protected vinyl amines. 

In a complementary approach, Larry Overman of the University of California at Irvine, has developed (J. Org. Chem. 2004,69,8101) a Co catalyst that effects the rearrangement of allylic imidates such as 9 with high . There is no need for the starting allylic alcohols to be perfectly trans, as imidates from cis allylic alcohols do not participate in the rearrangement. 

Larry Overman also used (J. Am. Chem. Soc. 2004,126, 14043) a chiral pool starting material, but in a different way. The prochiral enolate 12 showed substantial diastereoselectivity in its reaction with the bis-triflate 13, almost 10 1. Through the power of algebra, it followed that the three diastereomers of 14 were formed in a ratio of 90 9 1. The crystalline 14 was easily isolated in diastereomerically-pure form, and carried on to phenserine 15. This is a new method for the stereocontrolled construction of chiral quaternary centers. 

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