Overload of iron

More recently, the impact of excess iron on carcinogenesis has been studied. Toyokuni (2002) reported that in kidney cells of rats an overload of iron can result in carcinogenesis because of Fenton-reaction induced damage to a tumor suppressor gene. This is currently an active area of research. 

Yersinia enterocolitica Infection with Y. enterocolitica or Y pseudotuberculosis, together with haematogenous spread, may lead to a septic-typhoid course with hepatic and splenic abscess formation. Especially ulcerative colitis was frequently found to favour the formation of multiple liver abscesses. A genetic disposition is assumed in the presence of the HLA-B 27 gene. Patients with hepatic overload of iron are at special risk of Yersinia infection, since iron plays a major role in the metabolism of Yersinia. (18, 23, 28, 31, 32)... 

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