Overberger

Methyl 6-hydroxy-3-methylhexanoate is our 1,6-difunctional target molecule. Obvious precursors are cyclohexene and cyclohexadiene derivatives (section 1.14). Another possible starting material, namely citronellal, originates from the "magic box of readily available natural products (C.G. Overberger, 1967, 1968 E.J. Corey, 1968D R.D. Clark, 1976). 

C. G. Overberger, J.-P. Ansehne, andj. G. Lombardino, Organic Compounds with Nitrogen—Nitrogen Bonds, The Ronald Press Co., New York, 1966, Chapt. 4. 

Heidelberger. This tetraene has evoked a eonsiderable amount of interest both as regards its eonstitution and as a primary material for polymerisation. It has been prepared again from psewdopelletierine by Cope and Overberger, ° who record m.p. -5-8 to -5-4°, 1-5342, and describe... 

Prof. Charles G. Overberger, Department of Chemistry. The University of Michigan, Ann Arbor, Michigan 48109, U.S.A. 

Engr., Mark Bikales-Overberger-Menges (eds.) Vol. 9, pp. 337-379, Wiley, 1987. 

So far, many kinds of nucleophiles active for hydrolysis such as imidazolyl-, amino-, pyridino-, carboxyl- and thiol-groups, have been used for preparation of hydrolase models. Overberger et al.108,1091 prepared copolymers of vinylimidazole and acrylic acid 60 (PVIm AA), by which the cationic substrate, 61 (ANTI), was hydrolyzed. This kind of copolymer is considered to be a model of acetylcholinesterase. With ANTI, the rate of the copolymer catalysis was higher than that of imidazole itself in the higher values of pH, as is seen in Table 9. In this work, important contributions of the electrostatic interactions are clear. The activity of the copolymer was not as high with the negatively charged and neutral substrates. 

Overberger and associate110) also prepared copolymers of 6(6)-vinylbenzimid azole with acrylic add 62 (PBzJm - AA). In 40%-propanol water, the activities of the copolymers indicated a strong dependence on the carboxylate-benzimidazole-carboxylate triad. These effects were ascribed to strong electrostatic interactions between these sequences and substrates. 

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