Ouzo effect

Vitale SA, Katz JL (2003) Liquid droplet dispersions formed by homogeneous liquid-liquid nucleation The Ouzo effect . Langmuir 19 4105—4110... 

Nanocapsules can also be prepared by using the Ouzo effect [77], which utiKzes spontaneous droplet formation and subsequent polymer precipitation or synthesis. It is a preparation of metastable Hquid dispersions by homogeneous Kquid-Kquid nucleation, and is based primarily on a recent study conducted by Vitale and Katz [78]. This spontaneous emulsification occurs upon pouring, into water, a mixture of a totally water-miscible solvent and a hydrophobic oil (and optionally some water), thus generating long-Hved small droplets, which are formed even though no surfactant is present... 

S.A. Vitale, and J.L. Katz, Liquid droplet dispersions formed by homogeneous hquid-liquid nucleation The ouzo effect, Langmuir, 19 (10), 4105-4110, 2003. 

F. Ganachaud, and J.L. Katz, Nanoparticles and nanocapsules created using the ouzo effect Spontaneous emulsification as an alternative to ultrasonic and high-shear devices, ChemPhysChem, 6 (2), 209-216, 2005. 

Several preparation methods of uniform solid nanoparticles have been proposed in the literature. Generally, they can be classified as belonging to one of two groups the first one is a group of methods in which the nanoparticle synthesis requires the presence of a surfactant, while in the second one the preparation procedure takes place in the absence of surfactant. Surfactant-free methods include Stober synthesis [5] and solidification in spontaneously formed emulsions (the Ouzo effect) [6]. When surfactant is used during the synthesis the solidification occurs within the emulsion droplets. 

Lepeltier E, Bourgaux C, Couvreur P (2014) Nanoprecipitation and the Ouzo effect application to drug delivery devices. Adv Drug Deliv Rev 71 86-97... 

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