Other stabilized anions as nucleophiles nitriles and nitromethane

Note also that if the substrate has both aldehyde and ketone fnnctions the aldehyde will act as the electrophile. The ketoaldehyde shown forms the one 

If a five- or six-membered ring can form, then intramolecular aldol reactions nsnally occnr more rapidly than the corresponding intermolecnlar reactions between two molecnles of snbstrate. This provides a very nsefnl ronte to cyclic componnds (see Box 10.19). 

4 Other stabilized anions as nucleophiles nitriles and nitromethane 

An enolate anion behaves as a carbanion nucleophile, the carbonyl group stabilizing the anion by 

Accordingly, it is possible to generate analognes of enolate anions containing cyano and nitro groups, and to use these as nucleophiles towards carbonyl electrophiles in aldol-like processes. Simple examples are shown. 

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OTHER STABILIZED ANIONS AS NUCLEOPHILES NITRILES AND NITROMETHANE... 

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