Other Potential Indices of Proarrhythmic Liability

Increased TDR is an abnormal increase in the differences in action potential duration across the ventricular wall, between the left and right ventricles, or between the base and apex of the heart (Lagrutta and Salata 2006, p. 458). These authors further hypothesized that an iuCTease in TDR in the ventricle is the substrate of torsades. 

Assessment of T-wave morphology may also provide relevant information. Vincente and colleagues (Vicente et al. 2015) noted that patients with LQT2 can develop flat, asynunetric, and notched T waves while also noting that we do not know how additional block of calcium or late sodium channels, which decrease 

Albertson TE, Dean NC, El Solh AA et al (2010) Huoroquinolones in the meinagement of commumty-acquired pneumonia. Int J CUn Pract 64 378-388 

Bass AS, Darpo B, Bieidenbach A et al (2008) International Life Sciences Institute (Hetilth and Environmental Sciences Institute, HESl) initiative on moving towetfds better predictors of drug-induced torsades de pointes. Br J Pharmacol 154 1491-1501 

Bloomfield DM (2015) Incorporating exposure-response modeling into the assessment of QTc interval a potential alternative to the thorough QT study. Clin Pharmacol Ther 97 444-446 

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