Other Palladium-Catalyzed Cascade Reactions in Total Synthesis

3 Other Palladium-Catalyzed Cascade Reactions in Total Synthesis 

There is another important cascade sequence for the formation of a fused y-lactone unit from an o-disubstituted arene by direct intramolecular alkoxycarbonylation/lac-tonization promoted by palladium diacetate [50]. 

SCHEME 7.24 Palladium-catalyzed cascade reaction for the synthesis of a fnsed y-lactone. 

Palladium-catalyzed cyclization of allenes bearing a nucleophilic functionality has also been used widely for the construction of various types of heterocycles, and several cascade sequences were developed based on this cyclization reaction. Ergot alkaloids have been reported to exhibit broad biological activity, and several synthetic derivatives, such as pergolide and bromocriptine, were also used as antiprolactin and 

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Other palladium-catalyzed cascade reactions in total synthesis... 

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