Other Examples of Feedback Control

Servomechanisms play important roles in the regulation of several other pathways of mammalian metabolism, including the synthesis of purines (Wyngaarden and Kelley, 1978), pyrimidines (Levine et al., 1974), porphyrins (Meyer and Schmid, 1978), and sialic acids (Komfeld et al., 1964). A detailed discussion of each instance is beyond the scope of this chapter. Some examples of feedback control are cited in Table 1. 

Beta-hydroxy-beta -methyl glutarate-- mevalonic acid 

Fatty acyl-CoA Palmityl-CoA Uridine, cytidine derivatives (especially UMP and CMP) 

Free fatty acids (and CoA derivatives) Long chain acyl-CoAs 

Human liver Rabbit muscle Rat heart Chick liver Rat liver 

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