Other Anticancer Agents that Elicit Neuropathic Pain

Other Anticancer Agents that Elicit Neuropathic Pain 

Immune-modulating agents that prevent activation of immune cells (e.g., macrophages) and/or the inhibitory agents of inflammatory cytokines (e.g., neutralizing antibody) could prevent the neuropathic pain caused by vincristine. These agents could increase the tolerability of vincristine when used for the treatment of leukemia and lymphoma. 

Abbadie, C. (2005). Chemokines, chemokine receptors and pain. Trends Immunol. 26, 529-534. 

ReichJing, D. B., and Levine, J. D. (1996). Vincristine hyperalgesia in the rat A model of painful vincristine neuropathy in humans. Neuroscience 73, 259—265. 

Arruda, J. L., Sweitzer, S., Rutkowski, M. D., and DeLeo, J. A. (2000). Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat Possible immune modulation in neuropathic pain. Brain Res. 879, 216—225. 

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V. Other Anticancer Agents that Elicit Neuropathic Pain... 

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