Other Analogue and Bioisostere Databases

While Bioster appears to be without predecessor, several commercial and in-house databases and software tools dealing with bioisosterism and other common replacement techniques have been developed during the past decade (for details, see relevant publications [16-21] and reviews [5, 22-26]). Of the earlier related efforts, the CAVEAT program, based on large structure collections of tricyclic rings (TRIAD) and 

2) CTfile Formats, Symyx Solutions, Inc., http //accelrys.com/resource-center/downloads/freeware. 

3) ChemBase database software was distributed by Molecular Design Ltd, San Leandro, CA, USA. 

4) Bioster 10.1, Digital Chemistry Ltd, Sheffield, UK, http //www.digitalchemistry.co.uk/prod bioster. 

5) ISIS /Host and Isentris are available from Accelrys Inc., San Diego, CA, USA. 

---