Other Agents Used to Control and Treat Gastric Ulcers

Other Agents Used to Control and Treat Gastric Ulcers 

Several other agents besides the antacids, H2 blockers, and PPIs have proved successful in preventing or treating problems associated with gastric acidity and mucosal breakdown. Some of the more frequently used agents are discussed below. 

Metociopramide [ReglanJ. This drug is officially classified as a dopamine receptor antagonist but also appears to enhance the peripheral effects of acetylcholine. Primarily because of this latter effect, metociopramide stimulates motility in the upper GI tract (prokinetic effect), which may be useful in moving the stomach contents toward the small intestine, thus decreasing the risk of gastric acid moving backward 

Sucralfate [Carafate, Sulcrate). Sucralfate is a disaccharide that exerts a cytoprotective effect on the stomach mucosa.26,37 Although the exact mechanism is unclear, sucralfate may form a protective gel within the stomach that adheres to ulcers and shields them from the contents of the stomach. The protective barrier formed by the drug prevents further erosion and permits healing of duodenal and gastric ulcers. Sucralfate is well tolerated, although constipation may occur in some patients. 

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