Other Agents Targeting Mucosal Bile Acid Exposure

2 Other Agents Targeting Mucosal Bile Acid Exposure 

Aluminium hydroxide, which has been used widely as an antacid, also binds bile acids. However, there has been no clinical indication of altered CRC risk associated with its use and there was no observable difference in DMH-induced colorectal tumor incidence in rats receiving oral aluminium hydroxide compared with sham treatment.  

Alternative potential strategies for reduction of mucosal secondary bile acid exposure are to target deconjugation of glycine/taurine bile salts by bacterial bile salt hydrolases and/or bacterial 7-dehydroxylation of primary bile acids to secondary bile acids. Sequestration of bile acids in the intestinal lumen using probiotic bacteria has also been proposed as an area for future research.  

3 Therapeutic Anti-cancer Use of Bile Acid Conjugates 

High-throughput assay of bile acids is technically demanding and expensive. Combined with high intra- and inter-individual variability in stool bile acid levels, it is unlikely that bile acid measurement will find a role as a biomarker of future colorectal neoplastic risk. 

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