Osteoclasts lycopene effect

FIG. 15 Effect of lycopene on resorption of the calcium phosphate substrate coating of osteologic multitest slides in the presence of osteoclasts (Rao et al., 2003). (Lycopene I -Effect on osteoclasts Lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in ray bone marrow cultures. Reprint from Journal of Medicinal Food. 2003 6, pp. 69-78 by permission of Mary Ann Liebert, Inc., Publishers.)... 

The effects of lycopene on osteoclast formation and bone resorption were also reported by Ishimi et al. (1999) in murine osteoclasts formed in coculture with calvarial osteoblasts (Ishimi et al., 1999). Their results differed from those of Rao et al. (2003) in that they found that lycopene inhibited the PTH-induced, but not the basal, TRAP+ multinucleated cell formation. Furthermore, they could not demonstrate any effect of lycopene on bone resorption. They also did not study the effect of lycopene on ROS production. 

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