Osteoarthritis calcium salts

Clinical use Fenoprofen (Gruber, 1976 Brogden et al., 1977) is used as its calcium salt dihydrate in the treatment of rheumatoid arthritis and osteoarthritis at a daily dose of 1.2-3.0 g. The drug is rapidly absorbed and excreted with a plasma half-life of about 3 h despite being extensively bound (99%) to plasma protein. Fenoprofen is well tolerated, with dyspepsia being the main adverse effect. 

The controlled deposition of calcium salts is essential for the development of extracellular structures such as bones, teeth and shell. The process begins with uptake of calcium in the intestine, followed by transport, and then the laying down of structures. A complex system is necessary for the control of all these stages, and involves, for example, vitamin D, parathyroid hormone, calcium-binding proteins for transport, and a range of other proteins and polysaccharides for ordered deposition. Precipitation of calcium salts in the incorrect location can result in stone formation, osteoarthritis, cataracts and arterial disorders. 

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See also in sourсe #XX -- [ ]

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