Orthogonal dendrimer synthesis

The other accelerated approach for dendrimer synthesis, the orthogonal approach, involves convergent growth with two different monomers. The monomers, an AB2 and a CD2 must be carefully selected such that the focal functionalities of each individual monomer will only react with the periphery of the other monomer (B couples only with C and D only with A) thus removing the need for activation reactions. As... 

The only chemically homogeneous orthogonal synthesis capable of efficiently producing high generation dendrimers (Scheme 19) was reported by Free-... 

Although the orthogonal approach allows the rapid synthesis of dendrimers, and reduces the number of purification steps, few syntheses of this type have... 

FIGURE 54.11 Synthesis of polymer nanoparticles from alkynyl-functionalized micelles and azido-terminated dendrimers. (FromNew J. Chem., 31(5), O Reilly, R.K., Joralemon M.J., Hawker C.J., and Wooley K.L., Preparation of orthogonally-functionalized core click cross-linked nanoparticles, 718-724. Copyright 2007. Reproduced by permission of The Royal Society of Chemistry.)... 

Scheme 30.19 The rapid synthesis of a sixth-generation dendrimer using an orthogonal AB2 — CD2 divergent growth approach employing both thiol-ene and CuAAC click coupling reactions, (i) Thiol-ene coupling (ii) CuAAC (iii) Thiol-ene coupling (iv) CuAAC (v) Thiol-ene coupling (vi) CuAAC. Reproduced with permission from Ref [133] 2010, American Chemical Society.

A rapid, orthogonal synthesis of poly(benzyl ester) dendrimers via an "activated monomer approach. Org. Lett, 1, 685-687. 

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