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Orthoformic acid derivatives esters

The condensation of 1,4-diamines with a variety of carboxylic acid derivatives, e.g. imidate esters, orthoformic esters, /V-ethoxycarbonylthioamides (77JOC2530), nitriles and ethoxyacetylene, produces the cyclic amidine linkage —N = C(R)NH— (67AHC(8)2l, p. 40). Cyclic ureas, —NHC(0)NH—, have been similarly produced using carbonyl chloride, A, A -carbonyldi imidazole, carbon monoxide, thiocarbonyl chloride or carbon disulfide (67AHC(8)21, p. 38). [Pg.579]

These have the general formula R1,C(OR2)3 and are stable derivatives of the unstable ortho acids R-C(OH)3. Important examples are the esters of orthoformic acid (the orthoformates), which may be readily prepared by the interaction of the appropriate sodium alkoxide with chloroform (Expt 5.153). [Pg.699]

A 2- or 6-hydroxy-substituted purine can be prepared from the corresponding 4,5-diamino-pyrimidinol by cyclization with an acid, ester, ortho ester, or amide. If the ring closure is performed with reagents such as urea, alkyl chloroformates, urethanes, phosgene, and alkyl isocyanates, the 8-hydroxypurines are formed. Various xanthine and uric acid derivatives have been prepared by the condensation of 5,6-diaminopyrimidine-2,4-diols with formic acid. Purin-2-ol (1) was prepared by this route from 4,5-diaminopyrimidin-2-ol and ethyl orthoformate. ... [Pg.339]

The formamides 16 are intermediates. Formamide (Bredereck variant of the Traube synthesis [149]), formamidine, orthoformic ester, diethoxymethyl acetate, Vilsmeier reagent (fi om DMF and POCI3) and dithioformic acid are used as formic acid derivatives. 4,5-Diaminopyrimidines can be obtained from 4-aminopyrimidines 17 by nitrosation with HNO2 followed by reduction of the nitroso compounds 18 ... [Pg.411]

As stated above, the synthesis of quinazoline derivatives can also be conducted in two stages, i.e., by the reaction of isatoic anhydrides with ammonia, amides, and various compounds containing the NH2 group followed by cyclization of the obtained anthranilic acid derivatives. Thus, the amino amides 157, formed during the action of aqueous ammonia on the anhydrides 61 (yields 61-73%), were brought into reaction with orthoformic ester, and this led to the quinazolinones 158 (yields 53-78%) [79],... [Pg.25]

Triphenylacetic acid Ethylene derivatives from cyclic orthoformic acid esters... [Pg.211]

Orthoformic acid esters by transesterification with cleavage of 0,0-isopropylidene derivatives... [Pg.98]

The mixed ortho ester formed from tri(2-chloroethyl) orthoformate (100°, 10 min-2 h, 16% yield) is more stable to acid than is the unsubstituted derivative, but can be cleaved with 80% AcOH (20°, 1 h). ... [Pg.30]

A variety of cyclic ortho esters,including cyclic orthoformates, have been developed to protect czs-1,2-diols. Cyclic ortho esters are more readily cleaved by acidic hydrolysis (e.g., by a phosphate buffer, pH 4.5-7.5, or by 0.005-0.05 M HCl) than are acetonides. Careful hydrolysis or reduction can be used to prepare selectively monoprotected diol derivatives. [Pg.135]

In general, the O-alkylation of benzoxepinones is accomplished via the anion. Alternatively, an acid-catalyzed process employing ortho esters may be used. For the acid-catalyzed formal O-alkylation of l-chloro-8-methoxydibenz[ft,/]oxepin-10(ll//)-ones with triethyl orthoformate rather drastic conditions are required (hot concentrated sulfuric acid) to give the 10-ethoxy derivative 12 in excellent yield.109... [Pg.27]

The formation of porphyrins from 1,19-dideoxybi)enes-/r can be achieved starting either from the 1-methyl derivatives or from l,19-dideoxybilene-Z>-l,19-dicarboxylic acid esters. In the first case the desired methine bridge of the porphyrin stems from the 1-methyl group whereas in the latter case orthoformates have to be added in the condensation step as a precursor for the methine unit. The 1-methyl- and also 1,19-dimethyl-l,19-dideoxybilene- > salts can be cy-clized to the corresponding porphyrins with copper(II) acetate in methanol.56 However, when the bilenes contain /i-acceptor substituents, the yields of porphyrins obtained by this method are very low.57... [Pg.591]

Singular characteristics of the ruthenium catalysts are the capability of direct activation of different substrates (alcohols, ethers, formic,orthoformic and other carboxylic acid esters) at a low iodine concentration, and a high flexibility toward carbonylation and/or homologation processes for the substrates used. The catalytic activity of the ruthenium catalysts moreover do not strongly decrease, as occurs with Co or Rh systems, by passing from methyl to higher oxygenated alkyl derivatives. [Pg.220]


See other pages where Orthoformic acid derivatives esters is mentioned: [Pg.14]    [Pg.172]    [Pg.184]    [Pg.8]    [Pg.158]    [Pg.606]    [Pg.606]    [Pg.510]    [Pg.754]    [Pg.606]    [Pg.168]    [Pg.286]    [Pg.267]    [Pg.303]    [Pg.224]    [Pg.173]    [Pg.1221]    [Pg.253]    [Pg.417]    [Pg.302]    [Pg.414]    [Pg.275]    [Pg.302]    [Pg.414]    [Pg.204]    [Pg.14]    [Pg.173]   
See also in sourсe #XX -- [ Pg.12 , Pg.260 ]




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Ester derivation

Ester derivatives

Orthoform

Orthoformic acid derivatives

Orthoformic acid derivatives orthoformate)

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