Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Orthoclone OKT3 muromonab

Orthoclone OKT3 Muromonab-GD3 Ortho Biotech, Bridgewater, NJ Anti-CD3 Transplants 1986... [Pg.580]

Orthoclone/OKT3 (Muromonab-CD3) CD3 Mouse IgG2 Allograft rejection 1986... [Pg.278]

Orthoclone-OKT3 Muromonab-CD3 Murine IgG2a CD3 Organ Transplant IV 5 mg Daily (10-14 days)... [Pg.312]

Orthoclone Okt3 Muromonab-CD3 Ortho Biotech 6/1991 Reversal of acute kidney transplant rejection NA... [Pg.1425]

Orthoclone OKT3, muromonab-CD3 Murine IgGza CD3 Prevention of acute kidney, heart, and liver transplant rejection Ortho Biotech ... [Pg.428]

Smith SL. Ten years of orthoclone OKT3 (muromonab-CD3) a review. J Transplant Coord 1996 6 109-121. [Pg.459]

Muromonab-CD3 (Orthoclone OKT3) [Immunosuppressant/ Monoclonal Antibody] WARNING Can cause anaphylaxis monitor fluid status Uses Acute rejection following organ transplantation Action Murine Ab, blocks T-cell Fxn Dose Per protocol Adults. 5 mg/d IV for 10-14 d Peds. 0.1 mg/kg/d IV for 10-14 d Caution [C, /-] w/ Hx Szs, PRG, uncontrolled HTN Contra Murine sensitivity, fluid overload Disp Inj SE Anaphylaxis, pulm edema, fever/chills w/ 1st dose (premedicate w/ stCToid/APAP/antihistamine) Interactions t Effects W/ immunosuppressives t effects OF live virus vaccines t risk of CNS effects encephalopathy W/ indomethacin EMS Monitor for S/Sxs of Infxn monitor resp Fxn, known to... [Pg.228]

Sgro, C. (1995) Side-effects of a monoclonal antibody, muromonab CD3/ orthoclone OKT3 bibliographic review. Toxicology, 105, 23-29. [Pg.465]

Muromonab (Orthoclone OKT3 ) is a mouse monoclonal antibody that kills T lymphocytes, cells that are a part of the immune response. Muromonab, the first monoclonal antibody approved for use as a drug, is used to treat rejection of a donated kidney, liver, or... [Pg.74]

Muromonab-(CD3) Orthoclone OKT3) is a mouse monoclonal antibody that is a purified IgG. It is used for the prevention of acute allograft rejection in kidney and hepatic transplants and as prophylaxis in cardiac transplantation. It is also used to deplete T cells in marrow from donors before bone marrow transplantation. [Pg.661]

Dosage form Each 5 ml ampule of Orthoclone OKT3 contains muromonab-CD3 5 mg in a sterile solution. [Pg.289]

Pharmacokinetics A rapid decrease in T-lymphocytes is observed within a few minutes after administration of Orthoclone OKT3. The volume of distribution of muromonab CD3 is approximately 6.5 liters its half-life is 18 hours. Clinical experience has demonstrated that serum levels greater than or equal to 0.8pg/ml of muromonab CD3 blocks the function of cytotoxic T cells in vitro and in vivo. Reduced T-cell clearance or low plasma... [Pg.290]

Muromonab-CD3 monoclonal antibody Orthoclone OKT3 Acute rejection of heart, liver, and kidney transplants... [Pg.598]

Parenteral 40, 125, 500, 1000, 2000 mg powder for injection Muromonab-CD3 [OKT3] (Orthoclone OKT3)... [Pg.1361]

Murine mAbs are antibodies of murine origin. The first murine mAb to be approved for clinical use was muromonab-CD3 (Orthoclone OKT3 ), an mAb with CD3 on Tcells as the molecular target, and used in organ transplantation. [Pg.53]

Muromonab-CD3 Orthoclone OKT3 Ortho Biotech Anti-CD3 IgG2a Transplant rejection 1986... [Pg.591]

Muromonab-CD3 Orthoclone OKT3 (Ortho) Murine ant-CD3 Immunosuppressant (renal transplantation)... [Pg.1137]

USA muromonab-CD3 antibody Orthoclone OKT3 Murine MAb directed against the CD3 antigen of human T cells Immuno- suppressant... [Pg.460]

Muromonab Orthoclone OKT3 Johnson and Johnson murine mAb CD3 organ transplant rejection 1986 lgG2a -80%... [Pg.1151]

Anti-CD3 Monoclonal Antibodies Antibodies directed at the e chain of CD3, a trimeric molecule adjacent to the T-ceU receptor on the surface of human T lymphocytes, have been used with considerable efficacy in human transplantation. The original mouse IgG, antihuman CDS monoclonal antibody, muromonab-CD3 (OKT3, ORTHOCLONE okt3), stiU is used to reverse glucocorticoid-resistant rejection episodes. [Pg.918]

Muromonab-CD3 Orthoclone-OKT3 Murine Reversal of transplant rejection... [Pg.240]

See other pages where Orthoclone OKT3 muromonab is mentioned: [Pg.362]    [Pg.276]    [Pg.363]    [Pg.210]    [Pg.362]    [Pg.276]    [Pg.363]    [Pg.210]    [Pg.133]    [Pg.406]    [Pg.290]    [Pg.556]    [Pg.1207]    [Pg.114]    [Pg.376]    [Pg.1569]    [Pg.2397]    [Pg.264]    [Pg.473]    [Pg.721]   
See also in sourсe #XX -- [ Pg.3 , Pg.228 ]

See also in sourсe #XX -- [ Pg.3 , Pg.228 ]

See also in sourсe #XX -- [ Pg.3 , Pg.228 ]



SEARCH



Muromonab

Orthoclone

© 2024 chempedia.info