Organotin-Containing Polymers

If the material is employed externally there are additional reasons why polymers containing the organotin portion are favored over small molecules. First, regulations require use of bound tin for environmental reasons. Second, polymeric molecules are less apt to leach out remaining within the material longer offering 

The organotin-containing moiety may also be somewhat removed from the polymer chain as in the case of poly(tributyltin-4 -vinyl-biphenylcarboxylate) (Structure 17.3) where biphenylene spacers have been introduced [78,79]. 

The polymers may be synthetic as in the case of poly(vinyl alcohol) or may be natural as in the case of dextrin and cellulose where the products may again be either crosslinked (Structure 17.4) or linear (Structure 17.5) depending on the functionality of the reactant  

In either case, the products are composed of a variety of repeat units including unreacted units. 

The products may be cramected to the (Mganotin-containing moiety through noncaibon atoms such as oxygai, sulfur, and nitrogen, w through carbon atrxns (Structure 17.6). 

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The emphasis on organotin-containing polymers is the results of several factors. The first one involves the early discovery of their biological activity and more recently that these organotin compounds generally degrade to nontoxic inorganic compounds so that they are environmentally friendly. The second reason is the commercial availability of a wide... 

Some of the organotin-containing polymers inhibit Candias albicans, the yeast responsible for infections in humans better than commercially available applications while leaving the normal flora unharmed. Others inhibit methicillin-resistant Staphylococcus aureus (MRSA) (structure 11.22), preferentially. 

While organotin-containing polymers offer a wide variety of biological activities we will focus on their use in the inhibition of bacterial and yeast at this juncture of the paper. 

Following are microorganisms that have been successfully inhibited by condensation organotin-containing polymers including organotin polyamines. 

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