Organosilicon compounds introduction

The ever-increasing sensitivity of NMR spectrometers (higher magnetic field combined with a better circuitry) together with introduction of polarization transfer schemes for 29Si NMR have now removed for virtually all classes of organosilicon compounds the need to measure samples in high concentrations or as neat liquids (with its requirement for 1 g or more of the compound), as was the case in the sixties. 

Hosomi, A., Sakurai, H. Chemistry of organosilicon compounds. 99. Conjugate addition of allylsilanes to a,(3-enones. A New method of stereoselective introduction of the angular allyl group in fused cyclic a,p-enones. J. Am. Chem. Soc. 1977, 99, 1673-1675. 

H. W. Post, Silicones and Other Silicon Compounds, Reinhold Publ. Corp., New York, 1949 E. G. Rochow, An Introduction to the Chemistry of the Silicones, John Wiley and Sons, New York, 2nd ed, 1951 A. Hunyar, Chemie der Silikone, Verlag Techrtik, Berlin, 1952 R. R. McGregor, Silikones and Their Uses, McGraw-Hill Publ. Co., London, 1954 C. Eabom, Organosilicon Compounds, Butterworths Scientific Publications, London, 1960. 

Reduction to Alcohols. The organosilane-mediated reduction of ketones to secondary alcohols has been shown to occur under a wide variety of conditions. Only those reactions that are of high yield and of a more practical nature are mentioned here. As with aldehydes, ketones do not normally react spontaneously with organosilicon hydrides to form alcohols. The exceptional behavior of some organocobalt cluster complex carbonyl compounds was noted previously. Introduction of acids or other electrophilic species that are capable of coordination with the carbonyl oxygen enables reduction to occur by transfer of silyl hydride to the polarized carbonyl carbon (Eq. 2). This permits facile, chemoselective reduction of many ketones to alcohols. 

In Volume III of the series OrganosUicon Chemistry From Molecules To Materials the editors gave a comprehensive summary about the focus of basic research activities in the wide-spread field of organosilicon chemistry and cited the relevant literature. With respect to the title the introduction of this volume deals mainly with a summary of how to make silicon-containing compounds and... 

The presence of two leaving groups allows for the introduction of two different nucleophilic species. In addition to carbon, heteroatom nucleophiles have been used. A wide variety of heterocyclic derivatives are available when difunctional, nucleophilic compounds are treated with (1) (eq 5). The synthetic potential of all of these derivatives is as wide as organosilicon chemistry. ... 

---