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Organophosphorus nerve agents reactivity

Huang, H. Han, W. Noodleman, L. Grynszpan, F. Multiple reactive immunization towards the hydrolysis of organophosphorus nerve agents hapten design and synthesis. Bioorg. Med. Chem. 2001, 9, 3185-3195. [Pg.132]

Mercey, G., Verdelet, T., Renou, J., et ah, 2012a. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Acc. Chem. Res. 45,... [Pg.1086]

Even more reactive towards acetylcholinesterase are the organophosphorus derivatives developed as chemical warfare nerve agents, e.g. sarin. Such compounds react readily with the enzyme and form very stable addition intermediates. It is unusual to see fluoride as a leaving group, as in sarin, but its presence provides a huge inductive effect, thus accelerating the initial nucleophilic addition step (see also Section 13.7). [Pg.281]

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See also in sourсe #XX -- [ Pg.10 ]



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