Organolead compounds synthesis

In the last few years, the interest in organolead(rv) compounds has moved from preparative aspects more to the analytical detection of such compounds or their decomposition products. On the other hand, the synthesis and characterization of low-valent organolead compounds has experienced an impressive increase numerous remarkable results have been achieved, and these constitute the major part of this survey. 

Scheme 6. Arylation with an organolead compound as a key step in the synthesis of nor-neolignan.

Historically, the first metalloorganic method for the synthesis of organolead compounds was based on the use of zinc dialkyls. It was not surprising that the method was first... 

The tetraorganolead compounds are the best characterized of all the different types of organolead compounds, and tend to be the most stable and least reactive. Generally, they are formed as the major product in the synthesis reactions employed for organolead compounds and they serve as the starting material in the synthesis of other types of organolead compounds. 

As was mentioned in Section 1, the first synthesis of an organolead compound was reported by Lowig 210>211), who synthesized tetraethyllead by the reaction of a sodium-lead alloy with ethyl iodide. Some 35 years later, Polis 247,248) prepared the first aryl lead derivative by the reaction of bromobenzene with a sodium-lead alloy. Since 1923, the sodium-lead alloy-ethyl chloride reaction has been used for the commercial production of tetraethyllead. A similar reaction has also been used for the commercial production of tetramethyllead since 1960. The sodium-lead alloy-alkyl chloride reaction is discussed in Section 6. 

Organolead compounds of the RPbXs series (R = organic substituent) were unknown up to 1952. However, in 1935-1940, reported the synthesis of... 

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