Organogold derivatives

The reactivity pattern of some organogold derivatives is of interest. Thus, complex 90 oxidatively adds molecular chlorine, bromine, or iodine to yield the gold(III) product 103 (97JOM(544)91, 98JOM(552)69). The latter is... 

The reaction with active methylene compounds results in the hydrogen abstraction to give the alcohol and the organogold derivatives.178... 

Very recently, it was shown that a homoleptic rearrangement in the mononuclear organogold(III) derivative ]Au(C6F5)3(tht)] gives [Au(C6F5)4][Au(C6F5)2(tht)2] which was structurally characterized [41]. 

Further preliminary studies of direct auration of furane and thiophene derivatives were performed by Schmidbaur et al., who synthesised several organogold compounds similar to 89 or 90 [71] and the research of He and Shi on the gold(III)-catalyzed inter- or intramolecular functionalization of aromatic —H bonds confirmed the possibility of such processes [21] (Figure 8.2). 

An earlier review treated the organometallic derivatives, including alkyl, aryl, vinyl, alkynyl, carbonyl, carbene, alkene and alkyne complexes,16 and these will not be treated here (see Table 1 for other books and reviews on organogold chemistry). Two important articles dealing with [AuCl(CO)], including its structure and catalytic properties, have been published recently.97,381... 

The use of ferrocenyl derivatives has also led to the synthesis of other trinuclear organogold(I) complexes that usually contain the fragment C-Au-P. Some of them contain l,l/-bis(diphenylphosphino)ferrocene (dppf) bridging two gold(I) atoms and a variety of aryl groups (see Table XV). They have been prepared by treatment of the trinuclear chloro derivative [(ClAu)2(dppf)] with two equivalents of the corresponding aryllithium [Eq. (39)] and their photophysical and electrochemical properties have been studied.126... 

Probably the best-known pentanuclear organogold complex is the homoleptic complex [Au(p-mes)]5, whose synthesis by reaction of [AuCl(CO)] with the appropriate Grignard reagent in tetrahydrofuran solution [Eq. (50)] was first reported in 1983 by Floriani.143 An alternative synthetic procedure that takes place with precipitation of insoluble byproducts and uses a mesitylgold(I) derivative as a starting material [Eq. (51)] has been described more recently.31... 

Schmidbaur, H. Grohmann, A. Olmos, M. E. Schier, A. The Chemistry of Organic Derivatives of Gold and Silver. Synthesis and Uses of Organogold Compounds, Wiley, Chichester, 1999. 

In recent years The Chemistry of Functional Groups has included several volumes dealing with the chemistry of organometallic derivatives (five volumes edited by F. Hartley in 1982-1989), and The chemistry of organic germanium, tin and lead compounds (Ed. S. Patai, 1995). For the reason outlined below, this volume deals with the chemistry of organosilver and organogold compounds. 

Organogold compounds.34 Alkyl derivatives of gold were among the first organometallic compounds of transition metals to be prepared. Both gold(i) and gold(m) compounds with cr-bonds to carbon, as well as olefin complexes, are known. 

Oral gold treatment with a monovalent organogold compound has been used successfully to treat psoriatic arthritis in a patient simultaneously infected with HIV. The use of gold compounds in HIV-associated inflammatory arthritis and the possible antiretroviral effects of gold merit additional study. And reports of anti-HIV activity for cyanide and thioglucose derivatives of gold compounds may be even more significant. 

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