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Organocobalt complexes radical cyclizations

The cyclization reactions of organocobalt complexes are very useful, and they offer an excellent alternative to the tin hydride method when reduced products are not desired. Most cobalt cyclizations have been conducted with nucleophilic radicals. Precursors are prepared by alkylation of cobalt(I) anions, and are usually (but not always) isolated. One suspects that alkylcobalt precursors should be useful for slow cyclizations because there are no rapid competing reactions that would consume the initial radical (coupling of the initial radical with cobalt(II) regenerates the starting complex). [Pg.805]

These reactions are believed to proceed via a reductive process to give an organocobalt complex 37a, which undergoes an intramolecular cyclization of the radical 37b generated by homolytic cleavage of C-Co bond (Scheme 15). [Pg.142]

A tandem radical 5-exo cyclization/radical addition/allylic substitution reaction was subsequently described [292]. Allylic ot-bromo acetal 242b cyclized cobalt-catalyzed. Addition to diene 245 and subsequent coupling with coformed organocobalt(I) species generates an allylcobalt complex, which undergoes reductive elimination to cyclic product 246 in 93% yield (cf. Fig. 56). [Pg.261]


See other pages where Organocobalt complexes radical cyclizations is mentioned: [Pg.257]    [Pg.595]    [Pg.627]    [Pg.251]    [Pg.273]   


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Organocobalt

Organocobalt complexes

Organocobalt complexes cyclizations

Organocobalt radical cyclizations

Radical complexes

Radical cyclization

Radical cyclizations complexes

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