Organocatalytic Asymmetric Hydroamination

In the last decade, the field of asymmetric organocatalysis has seen significant 

The first and so far only example of catalytic asymmetric metal free hydroamination using the chiral phosphoric acid diester R) 58 was recently disclosed (Eq. 11.8) [111]. Although both selectivity and catalytic activity for the hydroamination ofthe secondary aminopentene 59 are rather low, the method itself remains very promising. 

Equation 11.8. Organocatalytic asymmetric hydroamination/cyclization ofa sec ondary aminoalkene [111]. 

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A.M., and MacMillan, D.W.C. (2009) Cycle-specific organocascade catalysis application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis. Angew. Chem., Int. Ed., 48, 4349 353 (f) Martin, N.J.A., Cheng, X., and List, B. (2008) Organocatalytic asymmetric transferhydrogenation of 3-nitroacrylates accessing / -amino acids. J. Am. Chem. 

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