Organocascade catalysis

SCHEME 6.5. Natural product synthesis through Diels-Alder based organocascade catalysis. 

MacMillan and co-workers demonstrated the capabilities of collective total synthesis in combination with organocascade catalysis very recently [53], which provided them a new synthetic strategy to achieve large collections of complex molecular architectures from a common molecular scaffold [54]. The power of this... 

We categorized the organocascade catalysis into a separated section as more and more organocatalysts have been used as a single catalyst or co-catalyst in various... 

Jones SB, Simmons B, Mastracchio A, MacMillan DWC (2011) Collective Synthesis of Natural Products by Means of Organocascade Catalysis. Nature 475 183... 

Simmons B, Walji AM, MacMillan DWC (2009) Cycle-Specific Organocascade Catalysis Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis. Angew Chem Int Ed 48 4349... 

Jones, S. B., Simmons, B., Mastracchio, A., MacMillan, D. W. C. 2011. Collective synthesis of natural products by means of organocascade catalysis. Nature 475 183-188. 

SCHEME 2.29 Organocascade catalysis with combination of azodicarboxylate and either indole or thiol derivatives. 

Bencivenni, G., Wu, L.-Y., Mazzanti, A., Giannichi, B., Pesciaioli, R, Song, M.-R, Bar-toli, G., Melchiorre P. (2009). Targeting structural and stereochemical complexity by organocascade catalysis construction of spirocyclic oxindoles having multiple stereocenters. Angewandte Chemie International Edition, 48, 7200-7203. 

Scheme 12.11 Organocascade catalysis with a,(3-disubstituted enals, indole, and azodicar-boxylate.

Simmons, B., Walji, A. M., Mac Millan, D. W. C. (2009). Cycle-specific organocascade catalysis appheation to olefin hydroamination, hydro-oxidation and amino-oxidation and to natural product synthesis. Angewandte Chemie International Edition, 48,4349-4353. 

The first example of dual organocascade catalysis involving iminium/enamine activation was published in 2005 (Scheme 35.15) [6]. In this report, a, 3-unsaturated... 

Organocascade Catalysis Combinations of Enamine and Iminium Catalysis [55]... 

Simmons B, Walji AM, MacMillan DWC. Cycle-specific organocascade catalysis application to olefin hydroamina-tion, hydro-oxidation, and amino-oxidation, and to natural product synthesis. Angew. Chem. Int. Ed. 2009 48(24) 4349-4353. 

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