Organic and Other Salts in Peptide Synthesis

FIGURE 8.14 Salts of amino acids. (A) Acetic acid and aqueous ammonia form salts with the basic and acidic amino acids but (B) not with neutral amino acids. (C) Stronger acids and bases form salts with all amino, guanidino and carboxyl groups of amino acids. Ac = acetyl R = alkyl or cyclohexyl. 

L Benoiton, LP Bouthillier. Synthesis of y-hydroxyglutamic acid (diastereomeric mixture). (isolation of amino acid with ion-exchange resin) Can J Chem 33, 1473, 1955. 

FMF Chen, NL Benoiton. Hydrochloride salts of amino acid benzyl esters from / -toluenesulfonates. Int J Pept Prot Res 27, 221, 1986. 

W Konig, G Breipohl, P Pokomy, M Birkner. Perchloric acid in peptide chemistry, in E Giralt, D Andreu, eds. Peptides 1990. Proceedings of the 21st European Peptide Symposium. Escom, Leiden, 1991, pp 143. 

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