Organ system studies dermal

Occupational and experimental studies have shown that the lung, liver, and hematopoietic system are the target organ systems following inhalation exposure to thorium. No relationship was found, however, between the measured body burden of thorium in exposed workers and complete blood count parameters (e.g., hemoglobin, red and white blood cell) (Conibear 1983). Target organs systems have not been identified for oral or dermal exposure to thorium. For further information on the health effects of thorium, see Section 2.2 of Chapter 2. 

Toxicology. The nitroparaffins have minimal effects by way of actual contact. There were neither systemic effects nor irritation in dermal studies in rabbits. Human exposure of a prolonged or often-repeated nature has led to low grade irritation attributable to removal of oil from the skin, an effect produced by most organic solvents. Eye irritation potential of all four nitroparaffins has been deterrnined in rabbits. Other than a transient slight redness and some lachrymation, no effects were noted. The average Draize score was 0.0. The acute oral toxicity, LD q, of all four nitroparaffins has been deterrnined in the rat (Table 8). 

Neurotoxicity. No clinical signs of central nervous system toxicity or histological alterations of nervous system organs and tissues were observed in rats or mice in the NCI (1978) chronic oral bioassay. Tests for neurotoxicity in animals may be appropriate if there is clinical evidence of neurological dysfunction in general oral or dermal toxicity studies of I 2-diphenylhydrazine. 

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