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Orexin system

Major efferent projections of the hypothalamic orexin system comprise descending and ascending, dorsal and ventral pathways that terminate preferentially in aminergic, endocrine, and autonomic control centers in the hypothalamus, midbrain, brainstem, and spinal cord, as well as in limbic cortical and subcortical structures, including sqDtum, amygdala, thalamus,... [Pg.910]

Hyperactivity of the orexin system, e.g. triggered by energy depletion, metabolic failure, hypoglycemia or hypoxia, in the context of starvation, sleep derivation, and stress, may predispose to addiction and... [Pg.912]

Alternate ways to interfere with the orexin system may be via inhibition of dipeptidyl peptidases or proteolysis-resistant peptide analogs as shown for other peptides. This could prolong and boost orexinergic signaling. OX-A but not OX-B can enters the brain by simple diffusion via the blood-brain barrier. Abundance of orexins and their receptors in the olfactory bulb and throughout all parts of the central olfactory system may offer transnasal routes for drug application. [Pg.913]

The phenotypic characterization of genetically modified rodents has advanced the understanding of both the basis of narcolepsy-cataplexy and the functions of the orexin system in the normal animal. Here we review the... [Pg.409]

See other pages where Orexin system is mentioned: [Pg.820]    [Pg.908]    [Pg.908]    [Pg.908]    [Pg.909]    [Pg.909]    [Pg.910]    [Pg.911]    [Pg.912]    [Pg.912]    [Pg.1136]    [Pg.205]    [Pg.298]    [Pg.318]    [Pg.404]    [Pg.407]    [Pg.420]    [Pg.48]    [Pg.820]    [Pg.908]    [Pg.908]    [Pg.908]    [Pg.909]    [Pg.909]    [Pg.910]    [Pg.911]    [Pg.912]    [Pg.912]    [Pg.1136]    [Pg.94]   
See also in sourсe #XX -- [ Pg.404 ]



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Orexins

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