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Orexin sleep

Mignot, E. (2004). Sleep, sleep disorders and hypocretin (orexin). Sleep Med. 5 (suppl. 1), S2-8. [Pg.171]

Hungs, M. Mignot, E. (2001). Hypocretin/orexin, sleep and narcolepsy. Bioessays 23, 397-408. [Pg.399]

Mazza, M., Della Marca, G., Paciello, N., Mennuni, G., Bria, P., and Mazza, S. 2005. Orexin, sleep and appetite regulation A review. Clin. Ter. 156, 93-96. [Pg.99]

Hyperactivity of the orexin system, e.g. triggered by energy depletion, metabolic failure, hypoglycemia or hypoxia, in the context of starvation, sleep derivation, and stress, may predispose to addiction and... [Pg.912]

Brown, R. E. (2003). Involvement of hypocretins/orexins in sleep disorders and narcolepsy. Drug News Perspect. 16, 75-9. [Pg.48]

Chemelli, R. M., Willie, J. T., Sinton, C. M. et al. (1999). Narcolepsy in orexin knockout mice molecular genetics of sleep regulation. Cell 98, 437-51. [Pg.48]

Lee, M. G., Hassani, O. K. 8r Jones, B. E. (2005). Discharge of identified orexin/ hypocretin neurons across the sleep-waking cycle. J. Neurosci. 25, 6716-20. [Pg.51]

Narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and cataplexy, may be caused by the lack of hypocretin mRNA and peptides in humans (Peyron et al., 2000) or a disruption of the hypocretin receptor 2 or its ligand in dogs and mice (Lin et al., 1999 Chemelli et al., 1999). Hypocretin-containing neurons are located exclusively in the dorsomedial, lateral, and perifornical hypothalamic areas (Peyron et al., 1998). Two hypocretin sequences, Hcrt-1 (orexin-A) and Hcrt-2 (orexin-B), are generated from a single preprohypocretin (De Lecea et al., 1998 Peyron et al, 1998 Sakurai et al, 1998). Axons from these neurons are found in the hypothalamus, locus coeruleus (LC), raphe nuclei, tuberomamillary nucleus, midline thalamus, all levels of spinal cord, sympathetic and parasympathetic centers, and many other brain regions... [Pg.95]

Figure 4.2 Model of the network responsible for paradoxical sleep onset and maintenance Abbreviations DRN, dorsal raphe nucleus 5-HT, serotonin LC, locus coeruleus NA, noradrenaline LDT, laterodorsal tegmental nucleus Ach, acetylcholine Me, magnocellular reticular nucleus Gly glycine DPMe, deep mesencephalic reticular nucleus PAG, periaqueductal gray DPGi, dorsal paragigantocellular reticular nucleus PPT, pedunculopontine nucleus PRN, pontine reticular nucleus SLD, sublaterodorsal nucleus Glu, glutamate Pef/HLA perifornical/lateral hypothalamic area Hcrt, hypocretin (i.e. orexin). Figure 4.2 Model of the network responsible for paradoxical sleep onset and maintenance Abbreviations DRN, dorsal raphe nucleus 5-HT, serotonin LC, locus coeruleus NA, noradrenaline LDT, laterodorsal tegmental nucleus Ach, acetylcholine Me, magnocellular reticular nucleus Gly glycine DPMe, deep mesencephalic reticular nucleus PAG, periaqueductal gray DPGi, dorsal paragigantocellular reticular nucleus PPT, pedunculopontine nucleus PRN, pontine reticular nucleus SLD, sublaterodorsal nucleus Glu, glutamate Pef/HLA perifornical/lateral hypothalamic area Hcrt, hypocretin (i.e. orexin).

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