Orexin neurons sleep-wake

Lee, M. G., Hassani, O. K. 8r Jones, B. E. (2005). Discharge of identified orexin/ hypocretin neurons across the sleep-waking cycle. J. Neurosci. 25, 6716-20. 

Grivel, J., Cvetkovic, V., Bayer, L. el al. (2005). The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation. J. Neurosci 25, 4127-30. 

Significantly, orexin/ataxin-3 mice respond to intracerebroventricular injection of orexin-A with increased wakefulness and suppression of REM sleep and cataplexy. This pharmacological reversal indicated that orexin receptors remain functional in the absence of orexin neurons, and that these narcoleptic mice can respond to orexin agonists, a finding with significant therapeutic implications (Mieda et al., 2004b). 

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