Orciprenaline Theophylline

Orciprenaline is somewhat beta2-selective compared with isoprenaline, but is by no means free of cardiac effects (1). Individual susceptibility to these varies, but it would seem that about one individual in 10 will experience tachycardia after usual therapeutic doses. At normal doses (for example 20 mg qds) jitteriness and nervousness are not uncommon, and about one patient in 12 suffers from cramps or numbness in the extremities. Lactic acidosis has been described in one patient as a result of concomitant use of orciprenaline, theophylline, and glucocorticoids. Other susceptibility factors and interactions are as for isoprenaline. 

Noninterfering aminophylline, beclomethasone, cloprednol, dexamethasone, fenoterol, ipratropium bromide, methylprednisolone, orciprenaline, prednisolone, reproterol, rimi-terol, salmeterol, sodium cromoglycate, theophylline... 

Simultaneous bromhexine, noscapine, tipepidine Noninterfering albuterol, orciprenaline, terbutaline, theophylline... 

Oral or inhaled orciprenaline has no effect on theophylline Cl, i.v. isoproterenol increases theophylline Cl by 21%. Oral terbutaline and inhaled albuterol may slightly increase theophylline Cl. ... 

In 6 healthy subjects orciprenaline 20 mg given every 8 hours by mouth or 1.95 mg given every 6 hours by inhalation for 3 days had no effect on the pharmacokinetics of theophylline (given as a single intravenous dose of aminophylline). This confirms a previous finding in asthmatic children. 

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