Oral drug delivery absorption variability

Recent years have witnessed an explosive growth in the imderstanding of the mechanisms associated with the absorption of drugs, especially therapeutic peptides and proteins. Scientists from a variety of disciplines continue to elucidate the variables associated with the optimal formulation and delivery of drugs via the oral mucosa. A greater rmderstanding of the para- and transcellular route of drug absorption, pro-... 

The advantages of transdermal delivery can be summarised as follows. Oral absorption in the neonate is unpredictable leading to variable drug levels in the plasma and drug input cannot be readily terminated after oral dosage. Intravenous therapy is complicated by the large dead volume of the access line compared to the small drug and plasma volume in preterm infants. 

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