Orai Proteins

Calcium channels in the plasma membrane activated after receptor-mediated calcium release from intracellular stores. Diese channels are present in many cellular types and play pivotal roles in a multitude of cell functions. It was recently shown that Orai proteins are the pore-forming subunit of CRAC channels. They are activated by STIM proteins that sense the Ca2+ content of the endoplasmic reticulum. 

Drug Aduit orai dose Onset Duration Haif-iife Protein... 

Agonist pKa Unionised (%) Lipid soiubiiity Protein binding (%) Orai avaiiabiiity (%) CL (L/min) VDSS(Lyi(h) ... 

D. Pharmacokinetics. Onset of CNS depressant effects begins within 10-15 minutes after orai ingestion of GHB and 2-8 minutes after intravenous injection. Peak ieveis occur within 25-45 minutes, depending on the dose. A recent meai may reduce systemic bioavaiiabiiity by 37% compared to the tasting state. The duration of effect is 1-2.5 hours after anesthetic doses of 50-60 mg/kg and about 2.5 hours in nonintubated accidental overdoses seen in the emergency department (range 15 minutes-5 hours). The rate of elimination of GHB is saturabie. Piasma blood levels of GHB are undetectable within 4-6 hours after therapeutic doses. The volume of distribution (Vd) is variable due to saturable absorption and elimination. GHB is not protein bound. 

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